Anti-Aging Supplement

A Safe and Science-Backed Solution to Looking & Feeling Younger

Amino Alliance, anti-ageing, has been a success from the moment we launched into Anti-Aging qualities benefits everyone and Amino Alliance offers a way to gain some control over the process of ageing by regaining of maintaining vascular vitality, reversal of age-related symptoms of cellular metabolism and enhances an overall sense of wellbeing through improved deep sleep. This deep sleep also increases your growth hormone, on top of boosting your immune function.

Growing clinical evidence indicates that dietary L-arginine supplementation can reduce obesity, decrease arterial blood pressure, resist oxidation and normalize endothelial dysfunction to cause remission of type 2 diabetes. The potential molecular mechanism plays a role in modulating glucose homeostasis, promoting lipolysis, maintaining hormone levels, ameliorating insulin resistance, and fetal programming in the early stage.

The possible signalling pathway of the beneficial effects of L-arginine likely involves the L-arginine-nitric oxide pathway through which cell signal protein can be activated. Accumulating studies have indicated that L-arginine may have the potential to prevent and/or relieve type 2 diabetes via restoring insulin sensitivity in-vivo.

Further evidence shows anti-ageing effects of L-arginine on a cellular level, meaning that every aspect of physiological function is positively impacted by the presence of NO (Nitric Oxide) and there is ample scientific evidence to support this and many other claims related to this effect, far beyond the scope of what we can discuss here. We, therefore, urge all users to delve deeper into the fascinating world of NO and L-arginine as the source and give us feedback on your personal experience with Amino Alliance.

How Can Amino Alliance Slow Down, Even Initially Reverse Aging?

In order to understand the far-reaching beneficial physiological implications of proper L-arginine supplementation and conversion its important to understand two basic principles: Conversion from L-arginine to Nitric Oxide and the positive hormonal, signalling effects on the various tissues and all related cellular levels. The proper conversion only happens if L-arginine is correctly supported by ingredients that amplify and facilitate the time-release transition from solid-state to gasses state. 

Anti-ageing is essentially the result of slowing down cellular metabolism due to the process of decreased vascular decay. In a general sense, the preservation of the stable replacement of dead cells with new ones has an immediate positive impact on preserving good health, physical ability and the way we look. For millennia people searched and obsessed for the “Fountain of Youth,” that wonderful magic source for living forever, if not at least finding a way to a better life. While we can debate the benefits of living for hundreds of years, most of us agree that living just a few more years beyond 80 is quite an accomplishment in a world plagued by industrial toxic waste that seeps into the food chain and therefore into our bodies at an ever-growing rate. 

Amino Alliance was therefore specially developed by a professor of organic chemistry Arne van der Gen, PhD, to prolong that process of slow conversion for several hours during sleep, advancing the beneficial effects on the endothelial cells that surround the inner lining of the vascular system.

In the end what matters most is adding quality, not just years to life. We can do this by avoiding foods and liquids that are known to harm us, like coffee, alcoholic beverages, refined sugars and sodium, excessive sun exposure, animal-based foods (red meat, pork, chicken, farmed salmon/tilapia, unfermented dairy products, lack of sleep, stress, EMF radiation and environmental pollutants, (including industrial chemicals, exhaust gasses, pharmacology* and many synthetic food additives). 

Xenobiotics, the journey and impact of foreign particles that find their way into the human body, happens to be one of the specialities of professor Arne van der Gen. It serves us to have the formulator of Amino Alliance to also be an expert in making sure that the ingredients we ingest are non-toxic and have a specific purpose without harming us in any way. 

While ageing is a biological inevitable process and not a disease or pathological condition it is correlated with various skin and body pathologies, including degenerative disorders, organ function, benign and malignant neoplasms, or cellular mutation. The ageing process can, however, be retarded dramatically by restoring proper vasodilation, which is exactly what Amino Alliance does.

Let’s take a closer look at why we age and how Nitric Oxide helps:

Proper L-arginine conversion plays a role in numerous physiological processes including nitrogen and ammonia detoxification, improved immune function and growth hormone (GH) and insulin secretion. Recently a lot of attention has been placed on L-arginine’s ability to affect vascular endothelial function. The conclusion is that the use of L-arginine as a nutritional strategy potentially reverses the progression of vascular dysfunction with ageing and CVD. L-arginine has also been found to modulate vascular inflammatory and systemic hormonal function. 

The proper synthesis of NO requires a correct admixture of substrate and cofactors. The viscous nature of blood flow dragging along the vascular wall can cause stress on the vascular system. Via phosphorylation endothelial nitric oxide synthase (eNOS) is activated and nitric oxide diffuses into vascular smooth muscle cells, which then induces cyclic guanosine monophosphate (GMP)-mediated smooth muscle relaxation. 

This then regulates regional blood flow (ie, flow-mediated dilation). Other cofactors required for this reaction include oxygen, flavin, nicotinamide adenine dinucleotide phosphate (NADPH), heme, and tetrahydrobiopterin. Tetrahydrobiopterin adheres to the heme group of the N-terminal oxidase domain of NOS, stabilizing the dimer molecule Increasing enzyme activity and the affinity of NOS for arginine. Note that under normal conditions, eNOS, in the presence of sufficient BH4, accepts and stores electrons from NADPH to transform cosubstrates O2 and L-arginine into NO and L-citrulline (Figure 1). 

Furthermore, Tetrahydrobiopterin accepts electrons from a flavin in the C-terminus reductase domain of NOS during the synthesis of NO and L-citrulline, acting as a redox agent. Dysfunction in any of these important steps with ageing may set the reaction awry, reduce NO bioavailability, attenuate vasodilatation, and alter regional circulation and tissue perfusion.

The typical Western diet will supply a person with 3 to 6 g of L-arginine per day. Common dietary sources of L-arginine include nuts, dairy, soy proteins, meats and seafood with a bioavailability of approximately 60%, but most of this L-arginine is not converted by the body at therapeutic levels after “long bone growth” has stopped. This leads us to look for alternative sources for adequate L-arginine conversion. However simple this may seem, tests show that unless the L-arginine molecule is of the right type (L-pyroglutamate) and is surrounded by L-lysine and L-glutamine, L-arginine conversion into nitric oxide doesn’t take place at levels considered effective. 

While undergoing catabolic traumatic events like surgery during which growth and/or repair triggers are accelerated, L-arginine may become conditionally essential. Ageing expresses itself in the deterioration of numerous organ systems, such as lean tissue loss (ie, sarcopenia). Ageing and CVD has become synonymous with inflammation which undermines tissue integrity, and if repair is imperfectly matched to systemic demand, the inflammatory process often results in chronic tissue damage. Therefore, inflammation and oxidative stress are key factors in the pathogenesis of vascular damage with anti-ageing. Ageing may be thus be considered a catabolic/inflammatory state. The administration of L-arginine as a nutritional strategy will protect the vascular system from the ravages of ageing and disease. 

A double-blind, randomized crossover trial, of L-arginine or placebo on vascular endothelial function, shows that L-Arginine L-pyroglutamate significantly improved endothelial-dependent vasodilation (5.7% ±1.2%), whereas placebo had no effect. 

Supplementation: L-arginine supplementation proves its effectiveness as vascular prophylaxis against endothelial dysfunction by acute stressors. Cigarette smoking and consumption of a high-fat meal dramatically reduce endothelial function. Oral L-arginine taken prior to smoking or with a high-fat meal prevents the detrimental effect on endothelial function.

Killer Cells:

After years of observing the behaviour of L-arginine, if properly administered, concludes that conversion enhances immune function. In vivo tests (human trials) shows that increased plasma concentrations of L-arginine tighten the ability of lymphocytes to transform into natural killer cells and lymphokine-activated killer cells. Further data suggest that L-arginine, under conditions of protein malnutrition, enhances T-cell function and has an immunopreserving effect. Chronic kidney patients appear to find relief from L-arginine’s ability to reduce important inflammatory markers and reduce oxidative stress.

While many amino acids stimulate insulin secretion, L-arginine has been shown to be the most potent. Even though insulin resistance is associated with endothelial dysfunction, the good thing is that insulin itself can improve endothelial-dependent vasodilation independent of glucose via a release of NO as a result of the activation of phosphatidylinositol 3 (PI-3) kinase and Akt kinase.

Hormonal Implications:

The decline in GH secretion is closely related to ageing, and this, in turn, triggers a decline in muscle mass and bone mineral density as well as increases in adiposity, especially around the waist. The decline of GH is linked to the deterioration of several cardiovascular and immunological functions. 

Numerous studies have demonstrated that L-arginine is a potent stimulator of GH and patients with GH deficiency have reduced endothelial dysfunction, and adjustments of GH production quickly restores endothelial function.

Summary and Conclusions:                                                                    

The complexity of the ageing process never ceases to captivate researchers and a true understanding of the why’s opposed to the how’s will be an ongoing journey. It’s therefore still unclear why proper L-arginine conversion diminishes during the years past long bone growth. We do know, however, that the lack of endothelial function is devastating to our vascular system and all other body functions that depend on it. Cells need proper blood flow and a slow down increases exposure to chronic disease and overall decay. Metabolic function, digestive and cellular, relies heavily on cellular renewal. The sooner we maintain opposed to regain this basic process, by proper supplementation of L-arginine, the sooner we delay the eventually unavoidable grasp of the claws of time. 

References:
1. https://www.ncbi.nlm.nih.gov/pubmed/27356939